The field of antibody engineering has advanced significantly in the more than 30 years since the US Food and Drug Administration (US FDA) approved the first monoclonal antibody in 1986. Antibody-drug discovery remains pivotal today due to the high selectivity of antibody[...]
Read MoreTherapeutic antibodies, a class of biologic medications, have revolutionized the treatment landscape for diseases like cancer, autoimmune disorders, and infectious diseases. These antibodies modulate the immune system and aid in healing by targeting specific molecules involved in disease processes. Since their development[...]
Read MoreRecent advancements in our understanding of type 2 diabetes mellitus and atherosclerosis have highlighted the significant role of inflammation in their development. This realization opens up opportunities for novel therapeutic strategies to reduce the prevalence of these public health issues. TNF alpha[...]
Read MoreHybridoma technology is a technique that helps obtain monoclonal antibodies by combining a certain antibody that produces B cells with myeloma cells. Through the Hybridoma technology steps, the monoclonal antibodies are made. This method, which is regarded as being extremely reliable, can[...]
Read MoreSelecting the right protein purification method is important in achieving high yield and purity. The main aim of protein purification is to separate a single target protein from contaminating proteins to help investigate its structure and function. Protein purification is a key[...]
Read MorePhage display technology has revolutionized antibody discovery and engineering by allowing the presentation of large peptide or protein libraries on the surface of bacteriophages. This capability is particularly valuable in generating Phage Display Antibody Library, where millions to billions of unique antibody[...]
Read MoreThe immune system is a sophisticated network of cells, proteins, and organs that work together to defend the body against harmful pathogens. One critical mechanism the immune system employs to eliminate infected or malignant cells is Antibody-Dependent Cellular Cytotoxicity (ADCC). Central to[...]
Read MoreProteins are essential molecules that play significant roles in virtually all biological processes. They function as enzymes, hormones, antibodies, and structural components of cells. To study these proteins or use them in various applications, they must be isolated from complex biological mixtures,[...]
Read MoreAutoimmune diseases are complex disorders where the immune system mistakenly attacks the body's own tissues. Among the numerous cytokines involved in the regulation and mediation of immune responses, tumor necrosis factor alpha (TNF-α) major role. This blog explores the function of TNF-α[...]
Read MoreIn recent years, therapeutic antibodies have revolutionized the treatment landscape for various diseases, offering targeted and effective therapies with fewer side effects compared to traditional treatments. As a patient, understanding therapeutic antibodies empowers you to make informed decisions about your healthcare. This[...]
Read More