Cell Line Development
Cell Line Development
From target to therapy!
Collaborate with our cell culture teams to use our cutting edge technology, expertise, and a reputable and stable cell line through the use of our UCOE Gene Expression Systems in conjunction with our CHO-GS and Freedom CHO Platform.
The Cell Line Development (CLD) procedure starts after the lead candidate has been found and a vector has been created for the chosen host cell. The procedure is customized to meet the needs of the program and the molecule.
The vector is transfected into a monoclonal host cell line that can be used in production and will be able to produce high titers and the necessary product properties.
A research cell bank is created and a lead manufacturing cell line will be chosen at the conclusion of the CLD procedure.
We are able to offer our clients high-producing cell lines that are appropriate for their needs thanks to the combination of host cell line, vector, and rigorous selection.
Well characterized CHO –GS and CHO-S host cell line with documented history.
DNA to RCB in 9-12 weeks
GS selection system
Biosafety testing of cell line and bioanalytical protein characterization
High cell densities up to 40-60 million cells/mL, 80% viability -Protein titers up to 8 g/L
Robust, easy transfer to manufacturer CMO
Easy to scale, scalable to pilot and large scale
Feasibility to collaborate one to one
DNA to Protein material under one roof
Customer Driven Scope and performance
Feasibility to collaborate one to one
DNA to Protein material under one roof
Customer Driven Scope and performance
DNA to Pool Material
- Performance check of molecules in our ready-to-scale ® CHO platform
- Candidate evaluation & screening
- Early protein material supply
DNA to RCB
- Workflow optimized for shortest duration
- Maximal time saving fast decisions by our experts
- Interim data package for information
RCB submission for MCB
- CQA evaluation on clone level
- Control on Clone Selection
- One to One Data sharing and discussion
Timeline is for a standard IgG1 NBE – scope & timeline of analytical testing might vary depending on molecule & client‘s needs.
Connect with
GeNext Genomics
discuss your project requirements and receive a
customized quote.
GET IN TOUCH WITH US