Signal Transducer and Activator of Transcription
STAT proteins are intracellular transcription factors that mediate many aspects:
- Cellular immunity
- Proliferation
- Apoptosis
- Differentiation
STAT 3 Gene
STAT3 is considered as one of the most crucial member of the STAT family. STAT3 activation occurs via the phosphorylation of tyrosine residue (Y705) by JAK (Janus Kinase) and serine (S727) by MAPK and non-receptor tyrosine kinases. (image: Cell Communication and Signaling)
Over the previous decades, STAT 3 has turned out to be one of the most examined oncogenic transcription factors and exceedingly connected to disease commencement, movement, metastasis and chemo resistance.
It is the most important biomarker of Triple Negative Breast Cancer.
As of now STAT 3 antibodies have been investigated for leukemia, lymphomas, breast cancer, prostate cancer, lung cancer , hepatocellular carcinomas, head and neck cancer treatments.
For understanding the role of STAT3, It is equally important to study the functional epitope. GNG has developed various functional domains of STAT3 molecule for understanding its role in cell signaling and cascade.
GNG manufactures high grade STAT 3 Proteins, its fragment and domain specific for therapeutic discovery and its antibodies for research.
Proteins:
1)STAT3 85 kDA
2)STAT3 63 kDA
3)STAT3 28 kDA
4)STAT3 18 kDA
5)STAT 3 14 kDA
The Antibody Clone 1A10 binds to the STAT3 domain of 14kda. This antibody has been approved in different applications including ELISA, WB and IHC.
GNG has STAT3 Protein Fragments of various domain (85KDa , 63KDa and 14 KDa) to study the different role of the target in various cancer. Call or write to us on info@genextgenomics.com to assist you with quality proteins and antibody.
Also Read: Use Of Monoclonal Antibody In Cancer Treatment